Tinnitus is a constant and chronic ringing in the ear which is making the life of 600 million difficult
worldwide. Henry Ford Health Systems along with Michigan Ear Institute has launched a campaign of
several clinical trials to test a new drug aimed at curing tinnitus and providing relief to the millions
In the study, a gel called AM-101 is injected into the middle ear of the patient to check the safety and
effectiveness of the drug in reducing the signals that are sent to the brain in case of acute inner ear
tinnitus. This acute inner ear tinnitus is most often due to the noise trauma or infection.
AM-101, in a way deactivates some specific receptors present in the inner ear which are supposed to
cause the problem of tinnitus. This inhibition of receptors was first confirmed in animals before checking
it on humans.

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Henry Ford and MEI happen to be just two of the 70 odd centers taking part in this initiative of National
Institute of Health-supported study.
A few advanced researches claim that although tinnitus starts in the ear, over time, it gets centralized in
the brain where it persists even after the original sight of damage has been treated in the inner ear.
Michael D. Seidman, M.D., director of the Division of Otologic/Neurotologic Surgery in the Department
of Otolaryngology-Head & Neck Surgery at Henry Ford confirms this. He added that since cure of a
permanent tinnitus is unavailable, attempts are being made at preventing severe tinnitus from
happening and treating the problem in its early stages. All the studies and trials are focused around
inner ear which is thought to be the center of tinnitus.

Tinnitus affects more than 10 percent of the American service men and women as they are exposed to
very loud sounds of guns, explosives and other machinery. As a result, hearing is one of the major
problems faced by people in the army and the Government is planning to spend close to 2 billion dollars
to treat this.

Apart from acoustic trauma, barotrauma, operation on the middle ear, traumatic perforation of the
eardrum or middle ear infection can also lead to Tinnitus in the inner ear. In most cases, tinnitus is
temporary and goes away but in case it persists, you should see a doctor and avoid activities that can
delay the healing process.